The Facile Synthesis of Pentane-1,5-diamines from Glutaraldehyde and Secondary Amines with Tetracarbonylhydridoferrate

摘要

Ethanolic tetracarbonylhydridoferrate solution combined with glutaraldehyde is a very effective reducing agent for the selective transformation of two moles of secondary amines into pentane-1,5-diamine derivatives. A variety of aliphatic secondary amines react with ferrate-glutaraldehyde at room temperature under carbon monoxide to give the corresponding N-substituted pentane-1,5-diamines in reasonable yields.