Synthetic ￥a-Lactam Antibiotics ￥±. Synthesis and Antibacterial Activity of 7￥a-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins

摘要

Syntheses of cefotaxime analogs with halosubstituted phenyltetrazolthiomethyl at the C3-position are described. Their in vitro potency was established. The compounds exhibited a broad antibacterial spectrum. Some of these compounds showed activity against Gram-positive bacteria superior to the parent cefotaxime. Against Gram-negative bacteria, these compounds are less effective than cefotaxime.