CRYSTALLIZED SALTS OF 7B- (2- (2-AMINOTHIAZOL-4-YL) ACETAMIDO) -3- ((((1- (2-DIMETHYLAMINOETHYL) -1H-TETRAZOL-5-YL) THIO) METHYL) 3-CEPHEM-4 -PIVALOYLOXYMETHYL CARBOXYLATE AND THEIR PREPARATION PROCESS

摘要

THE INVENTION RELATES TO CRYSTALLIZED CEPHALOSPORIN SALTS WHICH ARE THE CRYSTALLINE ADDITION SALTS OF 7B-2- (2-AMINOTHIAZOL-4-YL) ACETAMIDO-3-1- (2-DIMETHYLAMINO-ETHYL) 1H-TETRAZOL-5- YL THIOMETHYL-3-CEPHEM-4-PIVALOYLOXYMETHYL CARBOXYLATE WITH HYDROCHLORIC ACID, TARTARIC ACID OR CITRIC ACID. THESE SALTS ARE VERY STABLE AND EASILY ABSORBABLE BY THE INTESTINAL APPARATUS WITH FEW DIFFERENCES FROM ONE ANOTHER WHEN THE SALT IS ORAL. /P P FIGURE 1 GIVES THE SPECTRUM OF DIFFRACTION OF X-RAYS OF CRYSTALLIZED DICHLORHYDRATE AS WELL AS AMORPHOUS DICHLORHYDRATE.