Performance of HPLC Chiral Stationary Phases with Two Chiral Units and the Effect

摘要

Two chiral stationary phases (CSPs) derived from two diastereomers consisting of (R)- or(S)-メ-naphthylethylamine and (S)-naproxen were found to show different chromatographic behaviors in resolving N-(3,5-dinitrobenzoyl)-メ-arylalkylamines and N-(3,5-dinitrobenzoyl)-メ- or モ-amino amides and esters. From the different chromatographic resolution behaviors on the two CSPs, the chiral recognition is proposed to be controlled mainly by the (R)- or (S)-メ-naphthylethylamine part of the CSP. In contrast, the (S)-naproxen part of the two CSPs is proposed to exert some subordinate effects on the chiral recognition.