Change in paternity, risk of placental abruption and confounding by birth interval: a population-based prospective cohort study in Norway, 1967–2009

摘要

Objectives We examined abruption risk in relation to change in paternity, and evaluated if birth interval confounds this association. Setting Population-based study of singleton births in Norway between 1967 and 2009. Participants Women who had their first two (n=747?566) singleton births in the Norwegian Medical Birth Registry. The associations between partner change between pregnancies and birth interval were examined in relation to abruption in a series of logistic regression models. Primary outcome measures Risk, as well as unadjusted and adjusted OR of placental abruption in relation to change in paternity and interval between births. Results Among women without abruption in their first pregnancy, the risks of abruption in the second pregnancy were 4.7 and 6.5 per 1000 in women who had the same and different partners, respectively (OR=1.39, 95% CI 1.26 to 1.53). After adjustments for confounders including birth interval and smoking, partner change was not associated with abruption (OR=1.01, 95% CI 0.79 to 1.32). Among women with abruption in the first pregnancy, the association between partner change and abruption in the second pregnancy was 0.98 (95% CI 0.75 to 1.28). Interval 1?year was associated with increased abruption risk in the second pregnancy among women with the same as well as different partners, but interval over 4?years was only associated with increased risk among women with the same partner. No such patterns were seen for recurrent abruption. Conclusions We find no evidence that a change in partner is associated with increased abruption risk. Theories supporting an immune maladaptation hypothesis afforded by change in paternity are not supported insofar as abruption is concerned.