To study tumor motion and planning target volume margins using four dimensional computed tomography for cancer of the thorax and abdomen regions

摘要

In this study, four dimensional computed tomography (4DCT) scanning was performed during free breathing on a 16-slice Positron emission tomography PET /computed tomography (CT) for abdomen and thoracic patients. Images were sorted into 10 phases based on the temporal correlation between surface motion and data acquisition with an Advantage Workstation. Gross tumor volume gross tumor volume (GTV) s were manually contoured on all 10 phases of the 4DCT scan. GTVs in the multiple CT phases were called GTV4D. GTV4D plus an isotropic margin of 1.0 cm was called CTV4D. Two sets of planning target volume (PTV) 4D (PTV4D) were derived from the CTV4D, i.e. PTV4D2cm = CTV4D plus 1 cm setup margin (SM) and 1 cm internal margin (IM) and PTV4D1.5cm = CTV4D plus 1 cm SM and 0.5cm IM. PTV3D was derived from a CTV3D of the helical CT scan plus conventional margins of 2 cm. PTVgated was generated only selecting three CT phases, with a total margin of 1.5 cm. All four volumes were compared. To quantify the extent of the motion, we selected the two phases where the tumor exhibited the greatest range of motion. We also studied the effect of different PTV volumes on dose to the surrounding critical structures. Volume of CTV4D was greater than that of CTV3D. We found, on an average, a reduction of 14% volume of PTV4D1.5cm as compared with PTV3D and reduction of 10% volume of PTVgated as compared with PTV4D1.5cm. We found that 2 cm of margin was inadequate if true motion of tumor was not known. We observed greater sparing of critical structures for PTVs drawn taking into account the tumor motion.Keywords: four dimensional computed tomography, tumor motion and PTV margin reduction for thoracic and abdomen tumor