A Retrospective Database Study of Liraglutide Persistence Associated with Glycemic and Body Weight Control in Patients with Type 2 Diabetes

摘要

IntroductionIn both randomized controlled trials and real-world studies, liraglutide has demonstrated glycemic and body weight benefits in patients with type 2 diabetes. However, persistence with diabetes medication can be challenging. This study compared glycated hemoglobin (HbAsub1c/sub) and other outcomes in patients with type 2 diabetes who continued treatment with liraglutide for over 12?months with those who discontinued treatment earlier, in a real-life setting. MethodsThis is a retrospective study of adult patients with type 2 diabetes from Maccabi Healthcare Services in Israel, who initiated treatment with liraglutide from 2010 to 2015. Mean HbAsub1c/sub and body weight change from initiation to after 24?months was compared between patients who received liraglutide for at least 12?months (“continuers”) and those who discontinued within the first year (“discontinuers”). Adjustment for HbAsub1c/sub, body weight, and other potentially confounding factors was performed using 1:1 propensity score matching. ResultsThe 3580 patients comprised 2695 continuers and 885 discontinuers; 882 patients per group were matched. A significant ( p ?0.001) reduction in HbAsub1c/sub (– 0.80% vs – 0.32%) was seen in continuers compared with discontinuers, despite higher insulin usage (70.2% vs 59.0%; p ?0.001), and a higher proportion of patients using ≥?3 oral glucose-lowering drugs (20.6% vs 6.2%; p ?0.001) at 24?months among discontinuers. Mean body weight reduction was greater in continuers than discontinuers (3.57 vs 1.25?kg; p ?0.001). ConclusionIn a real-world setting, persistent use of liraglutide was associated with good glycemic and body weight control. FundingNovo Nordisk Health Care AG.