Effect of Albumin on Clinical Function after Acute Intracerebral Hemorrhage among Hospitalized Patients in Neurology Department of Ahvaz Golestan Hospital, Iran

摘要

BackgroundandObjective:Theaimofthisstudywastoevaluatetheeffectofthealbumininclinicalfunctionafteracuteintracerebralhemorrhage.SubjectsandMethods:Thestudywasadouble-blindclinicaltrialintwogroupofpatientwithhemorrhagicstroke,includingthosewithstrokeoccurredinthelast24hours.Thefirstgrouptreatedwithalbumininfusionwithtotaldoseof1g/Kgbodyweightfortwohoursperdayandthesecondgroupwastreatedwithnormalsalinewiththesamedose.Thetreatmentdurationwas7days.Functionaloutcomeofthefirstday,8thdaysand3monthsaftertreatmentwereinvestigatedonthebasisofNIHSS.ByChisquareandT-Testtatisticalanalysesandevaluationoftheeffectivenessoftheinterventioninthetwogroupswerestudied.Results:Eacharmofstudycontained30patients.Bothgroupswerethesimilarinage,sexandriskfactors.Therewerenotsignificantdifferenceinmortalityrate)P=0.353(,hospitalizationduration)P=0.343(andhematomasizebefore)P=0.596(andafter)P=0.483(treatmentintwogroups.NIHSSofthefirstday)P=0.474(andafter3months)P=0.095followingtreatmentdidnotshowsignificantdifferencesamongbothgroups.However,theresultatthe8thdayoftreatmentshowedsignificantdifferences(P=0.025).Conclusion:Thefindingsofthisstudyconfirmedthat,intravenousalbuminusedintheinitialdaysinthepatientwithhemorrhagicstrokewouldimproveshort-termclinicalandfunctionaloutcome,butthispositiveeffectisdiminishedinthelong-term.