Hydrocortisone plus fludrocortisone: Taichi of risk hedge for improving adults with septic shock

摘要

We read with interest the work presented by Annane et al . (1) in which the authors reported that hydrocortisone plus fludrocortisone therapy significantly improved 90-day all-cause mortality in patients with septic shock compared with placebo. Interestingly, recent work presented by Venkatesh et al . (2) did not favor hydrocortisone therapy alone in patients with septic shock undergoing mechanical ventilation.