Analytical Method for Simultaneous Determination of Pesticides and Pesticide Transformation Products in Water Environment Using GC-MS and LC-MS/MS

摘要

Exposure to chemicals and their transformation products is important for evaluating environmental risk. In this study, the analytical method for both pesticides and pesticide transformation products (PTP) in water environments was developed. Eleven pesticides were selected based on the amount of their use in Kanagawa, Japan. According to previous literature research for PTP which have been found in hydrolysis and/or photolysis, 77 PTP could be enumerated. Among them, 30 commercially available PTP and their 11 parent pesticides were tested in this study. The detection sensitivity for pesticides and PTP was evaluated using GC-MS and LC-MS/MS. Using GC-MS, 31 compounds could be detected with a limit of quantification (LOQ) of 10 - 50 ng/mL. To achieve detection of GC-MS-unfavorable compounds and more sensitive detection by LC-MS/MS, two atmospheric pressure ionization methods (electron spray ionization (ESI) and atmospheric pressure chemical ionization (APCI)) were assessed. Comparison of the LOQs demonstrated that the ESI method achieved more sensitive analysis than the APCI method. Also, LC-ESI-MS/MS showed higher sensitivity (