Volume reduction of benign thyroid nodules 3?months after a single treatment with high-intensity focused ultrasound (HIFU)

摘要

Background High-intensity focused ultrasound (HIFU) is a promising, non-invasive technique in treating benign thyroid nodules (TNs). The aim of this study was to evaluate the efficacy of HIFU to induce clinically meaningful shrinkage in benign predominantly solid TNs and to identify variables that influence or predict the magnitude of TN volume reduction. Methods For each of ten subjects, HIFU treatment was conducted on a single nodule. Nodular volume was measured sonographically at baseline and at 3 months post-procedure. Nodular function and early treatment assessment was done scintigraphically. Results Median nodular volume reduction was 0.7 ml absolute and 48.8% relative to pre-interventional size (p?