Mutational Screening of the Negative Regulatory Region of Astrocyte Elevated Gene -1 Promoter in Hepatocellular Carcinoma Patients

摘要

Objective: This study is aimed to assess the correlation between negative regulatory region of AEG-1 promoter and genetic susceptibility to hepatocellular carcinoma in Iranian population. Methods: The negative regulatory region of human AEG-1 promoter was explored in 50 Iranian HCC patients. The PCR-sequencing method was used for investigating AEG-1 promoter polymorphisms. Results: This analysis did not reveal the presence of any deletions, insertions, or mutations in this region of AEG-1 promoter. Conclusion: Mutations in the negative regulatory region of AEG-1 promoter have no significant relevance with hepatocellular carcinoma. Nevertheless, to our knowledge, this is the first study to investigate the mutations of the negative regulatory region of AEG-1 promoter in HCC patient. The role of AEG-1 promoter played in HCC needs to be further studied.