Synthesis of tetrahydrokhusitone: Annulation of the cyclohexane ring by free radical and carbanionic sequence of reactions

摘要

The synthesis of norcadinane sesquiterpene tetrahydrokhusitone 1 has been achieved by a new method for annulation of cyclohexane ring involving a sequence of free radical δ-alkylation of the non-activated carbon atom and intramolecular carbanionic alkylation. (–)-Menthol was used as the starting compound.