Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population

摘要

Background Recent genome‐wide association studies (GWAS) in European ancestry populations revealed several genomic loci for atrial fibrillation (AF). We previously replicated the 4q25 locus (PITX2) and 16q22 locus (ZFHX3) in the Chinese population, but not the KCNN3 locus on 1q21. With single‐nucleotide polymorphism rs3807989 in CAV1 encoding caveolin‐1, however, controversial results were reported in 2 Chinese replication studies.