首页> 外文期刊>Journal of the American Society of Nephrology: JASN >Donor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients
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Donor-Specific HLA Antibody IgG Subclasses Are Associated with Phenotypes of Antibody-Mediated Rejection in Sensitized Renal Allograft Recipients

机译:供体特异性HLA抗体IgG亚类与过敏性肾移植受体中抗体介导排斥反应的表型有关。

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摘要

Donor-specific anti–histocompatibility leukocyte antigen antibodies (DSAs) have a strong and frequently considered universally deleterious effect on allografts. Preformed or de novo DSAs activate complement, induce endothelial cell proliferation, and mediate antibody-dependent cellular.
机译:供体特异性抗组织相容性白细胞抗原抗体(DSA)对同种异体移植物具有强大且通常被认为是有害的作用。预制的或从头开始的DSA激活补体,诱导内皮细胞增殖,并介导抗体依赖性细胞。

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