Agomelatine Efficacy in Treating First-Episode Senile Depression

摘要

Objective: To investigate agomelatine effects on first-episode senile depression patients. Methods: One hundred and sixteen elderly patients with first-episode senile depression were randomly and evenly divided into an observation group and a control group. The observation subjects were treated with agomelatine. The control subjects were treated with sertraline. The treatment effects, sleep improvement, and adverse reactions were compared. Results: After one week of treatment observation group The Hamilton Depression Rating Scale (HAMD) and Pittsburgh Sleep Quality Index (PSQI) scores after one week of treatment decreased significantly. After two weeks of treatment control group scores also decreased significantly (p p p p Conclusion: Both agomelatine and sertraline are effective in treating first-episode depression elderly patients. Agomelatine has an earlier response, fewer adverse reactions and superior insomnia improvement.