BREAST CANCER SURGERY DECREASES SERUM BRAIN-DERIVED NEUROTROPHIC FACTOR CONCENTRATIONS IN MIDDLE AGED WOMEN: RELATIONSHIP TO THE SERUM C-REACTIVE PROTEIN CONCENTRATION

摘要

The aim of this study was to establish the effect of breast cancer surgery in middle aged women on the serum (s) and plasma (p) brain-derived neurotrophic factor concentrations [BDNF]s and [BDNF]p, respectively, in relation to the serum C-reactive protein [CRP]s concentration measured before and at 24 hours after surgery. Eighteen patients with recently diagnosed breast cancer (mean ± SE): age 49.1 ± 1.6 years, body mass 69.8 ± 2.2 kg, BMI 25.8 ± 0.8 kg m–2 , participated in this study. The [BDNF]s before the surgery amounted to 25 523 ± 1 416 pg ml –1 . At 24 h after the surgery it decreased to 21 551 ± 998 pg ml –1 (P = 0.004). This decrease was accompanied by a significant (P = 0.001) decrease in the platelet count (PLT) from 254.7 ± 12.2 k μl –1 before, to 228.8 ± 9.7 k μl –1 after the surgery. The [CRP]s increased from 3.59 ± 0.79 mg l –1 before to 25.04 ± 4.65 mg l –1 after the surgery (P = 0.002). A significant positive correlation was found between the [BDNF]s and the PLT both before (P = 0.003) as well as after the surgery (P = 0.027). Moreover, a significant positive correlation (P = 0.046) was found between [BDNF]s and the [CRP]s before the surgery. At 24 h after the surgery the [BDNF]s and the [CRP]s still correlated positively (P = 0.044), despite the fact that the surgery significantlly decresed the [BDNF]s and increased [CRP]s. No significant effect of the surgery on the [BDNF]p was found. We have concluded that serum BDNF concentration in breast cancer patients positively correlates with serum CRP both before and at 24 h after the surgery. Moreover, breast cancer surgery decreases serum BDNF concentration at 24 h after operation and increases [CRP]s.