In VitroandIn VivoEvaluation of Oxatomideβ-Cyclodextrin Inclusion Complex

摘要

The objective of this study was to evaluate the influence of oxatomideβ-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomideβ-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide andβ-cyclodextrin in presence or absence of water soluble polymers using different techniques. The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency(P<0.05)compared to the pure oxatomide. Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide. In conclusion, inclusion complex of oxatomide withβ-cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.