Synergistic effect of decellularized annulus fibrous matrix and substrate elasticity on annulus fibrous-derived stem cells

摘要

Background: Due to the similarity of biochemical composition and microstructure between decellularized matrix (DCM) and native extracellular matrix (ECM), DCM have been widely used in tissue engineering. Meanwhile, the effects of mechanical property (e.g. elasticity) of cell culture substrate on the proliferation and differentiation of cells have also been well documented. This study aims to explore the combined effect of decellularized annulus fibrous matrix (DAFM) from porcine and substrate elasticity on the behaviors of rabbit annulus fibrous-derived stem cells (AFSCs).