Background: Some studies showed that copeptin, a hypothalamic hormone derived from the precursor of vasopressin, may be useful in the prediction of outcome of ischemic cerebral stroke. The aim of this work was to search if there is any correlation between serum copeptin, in the first day of ischemic stroke, and its clinical severity, radiological findings and also its predictive value of functional outcome in these patients.Methods: This study was conducted on 55 patients of both sexes with ischemic cerebral stroke admitted to Neurology Department, Menofyia University within 24 hours of the onset of ischemic stroke. Patients were subjected to general and neurological examination, laboratory assessment (routine and serum level of copeptin), and brain computerized tomography (CT), or magnetic resonance imaging (MRI). The anatomical site of stroke was evaluated by using the Oxford Community Stroke Project (OCSP) classification. The etiological subtypes of stroke were classified according to Trial of Organization 10172 in Acute Stroke Treatment (TOAST) classification. Stroke severity was evaluated by Scandinavian stroke scale (NIHSS) and disability by modified Rankin scale (MRS) at admission and at 30 days.Results: The results showed high statistically significant correlation between the mean value of copeptin level and severity of stroke on admission (P < 0.001), and also with the size of the infarction (P < 0.001). There was statistically significant difference (P = 0.011) of copeptin level among the studied groups regarding the site of stroke. Additionally, there was high statistically significant difference (P < 0.001) between copeptin level and the etiological subtypes of stroke. The favorable outcome of the stroke was with cutoff point of copeptin below 21.5 ng/mL.Conclusion: Serum copeptin may help in the prediction of severity of ischemic stroke, its size, site, etiological subtypes and functional outcome.J Neurol Res. 2016;6(2-3):41-45doi: http://dx.doi.org/10.14740/jnr377w
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机译：背景：一些研究表明，肽素（一种来自下垂加压素的下丘脑激素）可能有助于预测缺血性脑卒中的预后。这项工作的目的是寻找缺血性脑卒中第一天的血清肽素与这些患者的临床严重程度，影像学表现以及功能预后的预测价值之间是否存在任何相关性。缺血性脑卒中发作后24小时内，Menohyia大学神经病学部收治了55名男女患有缺血性脑卒中的患者。对患者进行了常规和神经系统检查，实验室评估（胶原蛋白的常规和血清水平）以及脑部计算机断层扫描（CT）或磁共振成像（MRI）。通过使用牛津社区中风计划（OCSP）分类评估中风的解剖部位。中风的病因亚型是根据组织10172在急性中风治疗（TOAST）分类中进行分类的。入院时和30天时通过斯堪的纳维亚中风量表（NIHSS）评估卒中严重程度，通过改良Rankin量表（MRS）评估残疾程度。结果：结果显示，肽素水平的平均值与入院时中风严重程度之间具有统计学意义的显着相关性（ P <0.001），以及梗死面积（P <0.001）。在研究组中，中风部位的肽素水平在统计学上有显着性差异（P = 0.011）。此外，中肽素水平与中风的病因亚型之间存在统计学上的显着差异（P <0.001）。结论：血清肽素可能有助于预测缺血性脑卒中的严重程度，大小，部位，病因亚型和功能预后。卒中的良好预后是肽素的临界点低于21.5 ng / mL。 2016; 6（2-3）：41-45doi：http://dx.doi.org/10.14740/jnr377w
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