A novel bone targeting delivery system carrying bone-forming and anti-bone resorption phytomolecule icaritin for prevention of steroid-associated osteonecrosis in rat model

摘要

Objective: The treatment strategy of steroid-associated osteonecrosis(SAON) is to promote bone formation and inhibit bone resorption inearly stages. We found a semisynthesized small phytomolecule namelyicaritin that presented the properties of osteogenesis and anti-boneresorption. The current study developed a novel bone-targeting injectable Asp8-liposome-icaritin (ASP-LP-ICT). As coupling of osteoblasts andosteoclasts play key roles in bone turnover, this study aims to reporton the histological and cytological evaluation of ASP-LP-ICT developedfor SAON prevention.