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Oral Microbiology – progress, myths and evidence

机译:口腔微生物学–进展,神话和证据

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This presentation aims to address some of the significant advances in oral microbiology that have taken place since the last EOMW. The use of high throughput, non-cultural approaches to describe the qualitative composition of oral microbial communities in different sites and in different populations, advanced imaging methodologies to define the community architecture of oral biofilms and progress in culturing organisms from the extensive “not yet cultivatable” catalogue are significant highlights. Collectively these approaches are providing unprecedented insights into the nature of the oral microbiome and its putative relationship to oral (and systemic) health and disease. These largely descriptive studies do not in themselves address the aetio-pathological mechanisms at play. However, these too are being progressed through the use of ever more sophisticated in vitro and in vivo model systems which are enabling a more complete understanding of, at least, the repertoire of host:bacterial interactio...
机译:本演讲旨在解决自上一次EOMW以来口腔微生物学的一些重大进展。使用高通量,非文化方法来描述不同地点和不同人群中口腔微生物群落的定性组成,采用先进的成像方法来定义口腔生物膜的群落结构,以及从广泛的“尚未耕种”开始的生物培养目录是重要的亮点。这些方法共同为口腔微生物组的性质及其与口腔(和全身)健康和疾病的假定关系提供了空前的见识。这些主要是描述性的研究本身并没有解决起作用的病因-病理机制。然而,这些也正在通过使用越来越复杂的体外和体内模型系统来进行,这些系统至少能够更全面地了解宿主:细菌相互作用的组成...

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