Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study

Ricardo A. Cruciani; Ella Dvorkin; Peter Homel; Stephen Malamud; Bruce Culliney; Jeanne Lapin; Russell K. Portenoy; Nora Esteban-Cruciani

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Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study

机译：癌症，疲劳和肉碱缺乏症患者补充左旋肉碱的安全性，耐受性和症状结果：I / II期研究

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Carnitine deficiency is among the many metabolic disturbances that may contribute to fatigue in patients with cancer. Administration of exogenous l-carnitine may hold promise as a treatment for this common symptom. Little is known about l-carnitine safety

机译：肉碱缺乏症是可能导致癌症患者疲劳的许多新陈代谢障碍之一。外源左旋肉碱的给药可能有望治愈这种常见症状。关于左旋肉碱安全性知之甚少

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《Journal of pain and symptom management.》 |2006年第6期|共9页
作者
Ricardo A. Cruciani; Ella Dvorkin; Peter Homel; Stephen Malamud; Bruce Culliney; Jeanne Lapin; Russell K. Portenoy; Nora Esteban-Cruciani;
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中图分类诊断学;
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1. L-carnitine supplementation for the management of fatigue in patients with cancer: An Eastern Cooperative Oncology Group phase III, randomized, double-blind, placebo-controlled trial [J] . CrucianiR.A., ZhangJ.J., ManolaJ., Journal of Clinical Oncology . 2012,第31期

机译：左旋肉碱补充剂治疗癌症患者的疲劳：东方合作肿瘤小组第三阶段，随机，双盲，安慰剂对照试验
2. L-Carnitine Supplementation for the Treatment of Fatigue and Depressed Mood in Cancer Patients with Carnitine Deficiency A Preliminary Analysis [J] . R. A. CRUCIANI, E. DVORKIN, P. HOMEL, Annals of the New York Academy of Sciences . 2004,第Nov期

机译：左旋肉碱补充剂治疗肉毒碱缺乏症患者的疲劳和抑郁情绪初步分析
3. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. [J] . Cruciani RA, Dvorkin E, Homel P, Journal of pain and symptom management. . 2009,第4期

机译：晚期癌症和肉碱缺乏症患者补充左旋肉碱：一项双盲，安慰剂对照研究。
4. Automatic Breast Cancer Cohort Detection from Social Media for Studying Factors Affecting Patient-Centered Outcomes [C] . Mohammed Ali Al-Garadi, Yuan-Chi Yang, Sahithi Lakamana, International Conference on Artificial Intelligence in Medicine . 2020

机译：自动乳腺癌队列从社交媒体侦查，用于研究影响患者以患者为中心的结果的因素
5. The symptom cluster of fatigue, pain and psychological distress and its impact on the quality of life in Chinese patients with breast cancer undergoing cancer treatment. [D] . So, Kwok-Wei. 2007

机译：中国正在接受癌症治疗的乳腺癌患者的疲劳，疼痛和心理困扰症状群及其对生活质量的影响。
6. L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III Randomized Double-Blind Placebo-Controlled Trial [O] . Ricardo A. Cruciani, Jenny J. Zhang, Judith Manola, -1

机译：左旋肉碱补充剂治疗癌症患者的疲劳：东部合作肿瘤小组三期随机双盲安慰剂对照试验
7. Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study [O] . Ricardo A. Cruciani, Ella Dvorkin, Peter Homel, 2006

机译：患有癌症，疲劳和肉碱缺乏患者的L-肉碱补充剂的安全性，耐受性和症状结果：I / II期研究

Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study

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