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Risk Factors and Clinical Aspects of Recurrent Invasive Cervical Carcinoma

机译:复发性宫颈癌的危险因素和临床意义

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Objectives Recurrence of cervical cancer is one of the important and plausible discussions in oncology especially in patients with advanced stages. The purpose of this study was to introduce probability invasive cervical carcinoma recurrence as well as determining characteristics and the prognostic factors of this entity. Methods A retrospective study was designed to identify risk factors and pattern of uterine cervical carcinoma recurrence evaluating the outcome of 36 registered patients. Recurrence was defined based on clinical or para-clinical documentation over at least 6?months after complete remission following surgery or radiotherapy. Treatment consisted of a radiosurgical combination and exclusive radiotherapy. Results Mean age in selected patients is 54.8?±?12.0?years. The pathological reports of primary diagnosis are squamous cell carcinoma in 94.44?% and adenocarcinoma in remaining patients. Mean duration of recurrence among patients is 2.75?±?1.5?years after the initial treatment. Metrorrhagia is mostly revealing symptom which patients present in recurrent episode. Usually, the recurrence of cervical cancer is presented in pelvic cavity locally. Marginal involvement is documented in 50?% of cases and lymph node in 33.3?% of patients with recurrent episode being involved. Most important prognostic factors are improper treatment (16.66?% of cases) after initial diagnosis. Conclusions Prognostic factors such as selection of appropriate method for treatment are an important point for reducing the rate of recurrence. Moreover, warning patients about symptoms and frequent episodes of follow up is necessary for early diagnosis of recurrence.
机译:目的宫颈癌的复发是肿瘤学中重要且合理的讨论之一,特别是对于晚期患者。这项研究的目的是介绍可能性浸润性宫颈癌复发以及确定该实体的特征和预后因素。方法回顾性研究旨在确定36例注册患者的子宫癌子宫颈癌复发的危险因素和类型。手术或放疗后完全缓解后至少6个月内,根据临床或辅助临床资料定义复发。治疗包括放射外科手术治疗和独家放射治疗。结果入选患者的平均年龄为54.8±12.0岁。初步诊断的病理报告为94.44%的鳞状细胞癌和其余患者的腺癌。初次治疗后患者的平均复发持续时间为2.75±1.5年。复发性出血主要表现为患者的症状。通常,子宫颈癌的复发在盆腔局部出现。边缘性受累的病例为50%,复发性淋巴结的患者为33.3%。初步诊断后,最重要的预后因素是治疗不当(占病例的16.66%)。结论选择合适的治疗方法等预后因素是降低复发率的重要因素。此外,警告患者注意症状和频繁发作对于早期诊断复发是必要的。

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