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A Study to Compare the Efficacy and Safety of Intravenous Iron Sucrose and Intramuscular Iron Sorbitol Therapy for Anemia During Pregnancy

机译:蔗糖铁和山梨醇肌注铁治疗妊娠期贫血疗效和安全性比较研究

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Aims and Objectives To compare the efficacy, safety, and rate of response of intravenous iron sucrose and intramuscular iron sorbitol therapy for anemia during pregnancy. Material and Methods 100 antenatal cases of gestational age 14–32?weeks were included in this prospective study. Cases were randomly divided into two groups. Group A, having 50 cases received intravenous iron sucrose, and 50 cases in Group B received intramuscular iron sorbitol. Response to therapy in both groups was studied and compared. Results The mean pretherapy hemoglobin in group A was 6.49?gm/dl and in group B was 6.48?gm/dl. The rise in hemoglobin after 4?weeks of starting therapy was 3.52?gm/dl in group A and 2.33?gm/dl in group B. The difference was statistically significant ( P
机译:目的和目的比较静脉注射蔗糖铁和肌注山梨糖醇铁治疗妊娠期贫血的疗效,安全性和反应率。材料和方法这项前瞻性研究包括100胎龄14-32周的产前病例。将病例随机分为两组。 A组有50例接受了蔗糖铁静脉注射,B组有50例接受了肌内铁山梨糖醇注射。研究和比较了两组的治疗反应。结果A组治疗前平均血红蛋白为6.49μg/ dl,B组为6.48μg/ dl。开始治疗4周后,A组血红蛋白升高为3.52μgm/ dl,B组为2.33μgm/ dl。差异有统计学意义(P <0.01)。 A组达到目标血红蛋白(≥11?gm / dl)的平均时间为6.37?周,B组为9.04?周。在A组中,有8%(四)例患者具有I级不良反应。在B组中,有24%(12)的病例具有I级不良反应。差异具有统计学意义(P =?0.027)。在这两组中,没有病例中断治疗。结论静脉内蔗糖铁比肌内铁山梨糖醇治疗妊娠期中度至重度贫血安全,方便,有效,起效快。

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