Gastric Emptying of a Carbohydrate-electrolyte Solution in Healthy Volunteers Depends on Osmotically Active Particles

摘要

Background: Preoperative ingestion of only clear fluids until 2 hours before induction of anesthesia is a common preoperative fasting regimen. Gastric emptying times, however, vary among clear fluids. We therefore investigated the gastric emptying of 2 clear glucose-electrolyte drinks. Method: A 2-way crossover study was performed in 10 healthy volunteers. After fasting, the volunteers drank 500 mL of either OS-1?, an oral rehydration solution, or Pocari Sweat?, a popular sports drink, over 3 minutes in a standing position. Magnetic resonance imaging was performed before, immediately after, and 30 minutes after the drinking of each test fluid. The difference in gastric emptying between OS-1? and Pocari Sweat? was evaluated by comparing gastric fluid volume, flow rate, and residual ratio. We also compared the flow rates of sodium, potassium, carbohydrates, and osmotically active particles in the 2 test fluids. Results: Gastric fluid volume 30 minutes after drinking was significantly smaller for OS-1? (76.0 ± 57.0 mL) than for Pocari Sweat? (158.1 ± 73.5 mL, p? (10.66 ± 3.34 mL) than for Pocari Sweat? (8.68 ± 3.02 mL/min, p? (21 ± 14% than for Pocari Sweat? (41 ± 19%, p? and Pocari Sweat?, whereas the flow rate of osmotically active particles did not. Conclusions: Gastric emptying is significantly faster for OS-1? than for Pocari Sweat?.