In vitro antibacterial activity of ethanol extracts of nine herbal formulas and its plant components used for skin infections in Southern Thailand

摘要

The antibacterial activities of different Southern Thailand medicinal plant formulas as well as their medicinal plant components were tested against skin and wound pathogens, includingStaphylococcus epidermidis, methicillin-resistant?Staphylococcus aureus,?Streptococcus pyogenes, multidrug-resistant (MDR)?Escherichia coli, MDR?Pseudomonas aeruginosa, and?MDR?Acinetobacter baumannii.? Nine medicinal plant formulas consisting of 41 medicinal plants were chosen on the basis of their traditional use against skin infections. The preliminary antimicrobial activity of the ethanol extracts formula was carried out by disc diffusion test. The extracts which showed inhibitory effect were further investigated for minimum inhibitory concentration (MIC) using the broth microdilution method. Eight formulas?were found to?inhibit?the growth of at?least one?of the tested?pathogens?with inhibition zones ranging from 7.5 to 21.0 mm. THR-SK004 and THR-SK005 extracts displayed broad spectrum activity against both Gram-positive and Gram-negative. Results indicated that THR-SK004 and its medicinal components,?Metroxylon sagu?Rottb. andOroxylum indicum?Vent.? exhibit good antibacterial activity with MIC values in the range of 30 to 1,000 μg/ml.??This antibacterial property tends to support the use of traditional medicine in the treatment of bacterial skin infections.