Antiviral activity of crude extracts of Synadenium glaucescens (Pax) against infectious bursal disease and fowlpox virus

摘要

The effect of crude extracts from different morphological parts of?Synadenium glaucescensagainst?infectious bursal disease virus (IBDV) and fowlpox (FP) virus using an?in ovo?assay were investigated. Viable 9 days embryonated chicken eggs?were challenged with viral strains then treated with?S. glaucescens?extracts at concentration of 0.2 mg/ml.?Un-inoculated group were saved as negative control and groups inoculated with virus and diluent saved as positive controls. The treatments were observed daily and embryo weights were measured?5 days post-inoculation. Embryo survival and mean embryo weight were significantly higher (P ≤?0.001) in groups treated with?S. glaucescens?extracts?than the positive control. More than 50% of the extract prevented death and deformation of embryo and formation of pock lesions in embryos. Furthermore, the treatments with ethanolic extract of the root bark demonstrated significantly higher mean embryo weight compared to other extract for both viruses (P?≤ 0.001). The mean embryo weights from eggs challenged with?infectious bursal disease virus and fowlpox virus?treated with the extract were 6.3 ± 2 and 5.9 ± 0.5 g, respectively.?These findings demonstrate potential and feasibility of using?S. glaucescens?extracts for?treatment of the viral diseases. Furthermore, it validates the ethnoveterinary?exploitation at community level.