Antimicrobial Studies of Mixed Ligand Transition Metal Complexes of Maleic acid and Heterocyclic Amine Bases

摘要

Mixed-ligand transition metal complexes of Co (II) ions were synthesized, where, Maleicacid as a primary ligands and heterocyclic amine bases as a secondary ligands have been used, respectively. Moreover, mixed-ligands transition metal complexes of Fe (III) ions were also synthesized by the same way. Their conventional physical and chemical analysis has been done. Their anti-bacterial and anti-fungal activity has been evaluated. Disc diffusion methods were employed for anti-microbial assays against 14 pathogenic bacteria (5 g positive and 9 g negative) and 14 fungi. The complexes containing 8-hyroxy-quinoline as secondary ligand were much more microbial activity than the other complexes. In addition, the complexes K[Co(II)(ME)(8-HQ)] shows the highest anti bacterial activity against all bacterial tasted (when, ME=C₄ H₂O₄ and 8-HQ=C₉H₆NO).