Thrombocytopenia as a presenting manifestation of sarcoidosis

摘要

Sarcoidosis is a chronic granulomatous disease involving multiple organs. Most commonly affected organs are lungs, followed by skin, lymph nodes. Hematological manifestations of sarcoidosis are uncommon and may include hemolytic anemia, leukopenia, eosinophilia, peripheral lymphopenia but severe thrombocytopenia is very rare. Our patient presented with petechial rash, papular skin lesions and had severe thrombocytopenia. Skin biopsy showed granulomatous inflammation without necrosis with good clinical, radiological and hematological response to oral prednisolone.