Expression of E-Cadherin in Squamous Cell Carcinoma of the Larynx and its Correlation with Clinicopathological Features

摘要

The purpose of this study was to define the frequency of E-cadherin underexpression and its correlation with clinicopathological behaviors of the tumor in Iranian patients with laryngeal carcinoma. In 95 paraffin-embedded specimens of patients with squamous cell carcinoma of larynx at our hospital from 2002 to 2007, the expression of E-cadherin was examined by immunohistochemical staining. To evaluate the correlation between E-cadherin expression and clinicopathological behavior, Chi-squared or Fisher exact test was used. Analysis of these samples showed reduced E-cadherin expression (Staining of less than 50% of the cells) in 79 (83.2%) patients. Reduced E-cadherin expression had correlation with tumor differentiation (p = 0.03). Also it had significant association with node involvement (p = 0.02) and tumor recurrence (p = 0.01). Determination of E-Cadherin expression might be useful in prognostic assessment. Whoever, to use it in clinical practice more studies are necessary.