Biodisposition Kinetics of Clarithromycin Following Oral Administration of 250mg Tablet in Human Male Volunteers

摘要

Biodisposition of drug was investigated in male volunteers following the oral dose of 250mg. Blood samples were collected after predetermined schedule and drug concentration was determined by microbiological assay. The two compartment model kinetics analysis of plasma clarithromycin concentration versus time data revealed that the average ± SD values of t_1/2?, clearance and volume of distribution are 1.36±0.14h, 20.43±3.04 l/h and 39.91±1.461 l/kg respectively. The absorption rate constant, area under curve (AUC) and mean resident time with ± SD are 0.51±0.05h, 12.36±1.43 h.mg/l and 4.17±43 h respectively.