Unusual Alveolar Pattern in Node Based Diffuse Large B-cell Lymphoma

摘要

Diffuse Large B-cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma worldwide. We present a case of 45 year old male patient presenting with swelling in right side of the neck since 6 months. A cytological aspirate of the lymph node suggested possibility of malignancy and excision biopsy was advised. Histopathology revealed a well-developed alveolar pattern with nests of dyscohesive large round tumour cells separated by delicate fibrovascular septae. Tumour cells were positive for CD45, CD20 and BCL-6 and negative for CD3, CD 5, CD 10, BCL-2, Desmin, Chromogranin, Synaptophysin and S-100. Based on histopathology and immunohistochemical findings, final diagnosis of DLBCL, NOS was given. The case is presented to highlight an unusual morphological alveolar growth pattern in DLBCL.