Reactions to Shrimp Including Severe Anaphylaxis in Mite- and Cockroach-Allergic Patients Who Have Never Eaten Shrimp: Clinical Significance of IgE Cross-Reactivity to Tropomyosins From Different Sources

摘要

Immunological cross-reactivity between shrimp, mites, cockroach, and Ascaris lumbricoides is thought to be due to IgE responses to shared allergens, particularly tropomyosin. IgE-binding homologous epitopes have been identified in invertebrate tropomyosins, thus indicating a structural basis for cross-reactivity between allergenic tropomyosins [1]. However, their clinical relevance is unpredictable. Tuano and Davis [2] described 4 mite-allergic patients with rhinitis with and without asthma, who developed oral allergy syndrome upon ingestion of shrimp, although their reaction did not progress to anaphylaxis during oral food challenges (OFC) [2].