Estimation of pre- and postradiotherapy blood selenium-dependent glutathione peroxidase levels in oral squamous cell carcinoma patients

摘要

Radiotherapy has been used successfully in the treatment of cancer for many years. It can be used as only treatment or in combination with other treatment modalities. Blood samples were collected of oral squamous cell carcinoma patients attending the Department of Oral Medicine and Radiology, Government Dental College and Hospital, RST Cancer Hospital and Research Centre. Nagpur and Department of Radiotherapy and Department of Biochemistry. Government Medical College and Hospital, Nagpur, before and after sixth week of radiation therapy. The effect of radiation on oral squamous cell carcinoma has been studied using activity of glutathione peroxidase enzyme- GPX Enzyme activity was significantly reduced in RBC hemolysate of oral cancer patient showing lack of antioxidant defense. Radiation treatment further inactivates the GPX enzyme, though insignificantly, by lipid peroxidation making system further inefficient.