Correlation of peripheral blood CCR7 expression with myocardial injury and inflammatory reaction in patients with acute coronary syndrome

摘要

Objective: To study the correlation of peripheral blood chemokine receptor 7 (CCR7)expressions with myocardial injury and inflammatory reaction in patients with acute coronarysyndrome. Methods: Patients who were diagnosed with stable angina pectoris, unstable anginapectoris, non-ST-elevation myocardial infarction and ST-elevation myocardial infarction inChengdu Fifth People’s Hospital between May 2014 and October 2016 were selected as SAPgroup, UAP group, USTEMI group and STEMI group respectively; healthy volunteers whoreceived physical examination during the same period were selected as control group. Theexpression of CCR7 in peripheral blood mononuclear cells and the contents of myocardialinjury and inflammatory response markers in serum were determined. Results: CCR7 mRNAexpression in peripheral blood mononuclear cells as well as serum IL-1, IL-6, IL-18, MMP2and MMP9 contents of UAP group, USTEMI group and STEMI group were significantlyhigher than those of SAP group and control group; serum CK-MB, Myo and cTnI contentsof USTEMI group and STEMI group were significantly higher than those of SAP group andcontrol group, and serum CK-MB, Myo and cTnI contents of UAP group were not differentfrom those of SAP group and control group; CCR7 mRNA expression in peripheral bloodmononuclear cells was positively correlated with serum CK-MB, Myo, cTnI, IL-1, IL-6, IL-18, MMP2 and MMP9 contents. Conclusion: Highly expressed CCR7 in peripheral bloodof patients with acute coronary syndrome can aggravate myocardial injury by activatinginflammatory reaction.