Correlation of peripheral blood CCR7 expression with myocardial injury and inflammatory reaction in patients with acute coronary syndrome

摘要

Objective:To study the correlation of peripheral blood chemokine receptor 7 (CCR7) expressions with myocardial injury and inflammatory reaction in patients with acute coronary syndrome.Methods: Patients who were diagnosed with stable angina pectoris, unstable angina pectoris, non-ST-elevation myocardial infarction and ST-elevation myocardial infarction in Chengdu Fifth People''s Hospital between May 2014 and October 2016 were selected as SAP group, UAP group, USTEMI group and STEMI group respectively;healthy volunteers who received physical examination during the same period were selected as control group. The expression of CCR7 in peripheral blood mononuclear cells and the contents of myocardial injury and inflammatory response markers in serum were determined.Results: CCR7 mRNA expression in peripheral blood mononuclear cells as well as serum IL-1, IL-6, IL-18, MMP2 and MMP9 contents of UAP group, USTEMI group and STEMI group were significantly higher than those of SAP group and control group;serum CK-MB, Myo and cTnI contents of USTEMI group and STEMI group were significantly higher than those of SAP group and control group, and serum CK-MB, Myo and cTnI contents of UAP group were not different from those of SAP group and control group;CCR7 mRNA expression in peripheral blood mononuclear cells was positively correlated with serum CK-MB, Myo, cTnI, IL-1, IL-6, IL-18, MMP2 and MMP9 contents.Conclusion: Highly expressed CCR7 in peripheral blood of patients with acute coronary syndrome can aggravate myocardial injury by activating inflammatory reaction.