Expression level and clinical significance of KLK7 and E-CAD in gastric cancer

摘要

Objective: To explore the expression level of klk7 and E-cad in serum of patients withgastric cancer and to explore the relationship of klk7 and E-cad with gastric cancer clinicalpathological characteristics. Method: A total of 50 patients with gastric cancer, and 50 healthypersons were selected as the experimental group, benign gastric disease group and healthygroup, respectively. A total of 24 patients in experimental group met surgery indications, andagreed to perform gastrectomy. They were divided into preoperative group and postoperativegroup. The serums levels of KLK7 and E-cad were detected by enzyme-linked immunosorbentassay. Results: The serum levels of KLK7 and E-cad were significantly higher than that ofbenign gastric disease group and normal control group. Compared with the experimentalgroup after operation, MMP-2 and MMP-9 were decreased, KLK7 was significantly decreasedand E-cad increased significantly after operation. Serum levels of KLK7 and E-cad inexperimental group stage I were increased and stage IV decreased. Microvascular invasionwas significantly correlated with serum KLK7 and E-cad. There was no significant correlationbetween tumor size, differentiation degree, depth and expression of KLK7 and E-cad. SerumKLK7 were significantly negatively correlated with E-cad expression in gastric cancer patients.Conclusions: KLK7 and E-cad are involved in the development and metastasis of gastriccancer. The serum expression of KLK7 and E-cad are significantly negatively correlatedin patients with stomach cancer. There may be an antagonistic effect in gastric cancerdevelopment and metastasis. Serum level of KLK7 and E-cad can be used as indexes forprogress monitoring.