Influence of hyperbaric oxygen combined with psychotropic drugs on serum neurotransmitter and cytokine contents in patients with post-stroke depression

摘要

Objective: To investigate the influence of hyperbaric oxygen combined with psychotropicdrugs on serum neurotransmitter and cytokine contents in patients with post-stroke depression.Methods: A total of 62 patients with post-stroke depression who were treated in the hospitalbetween January 2015 and February 2017 were divided into routine group (n=31) andhyperbaric oxygen group (n=31) by random number table method. Routine group receivedantidepressant therapy, hyperbaric oxygen group received hyperbaric oxygen combinedwith antidepressant therapy, and the therapies lasted for 8 weeks. The differences in theserum contents of monoamine neurotransmitters, inflammatory factors and oxidative stressindexes were compared between the two groups before and after treatment. Results: Therewas no statistically significant difference in serum levels of monoamine neurotransmitters,inflammatory factors and oxidative stress indexes between the two groups before treatment.After 8 weeks of treatment, serum monoamine neurotransmitters NE, 5-HT and DA contentsof hyperbaric oxygen group were higher than those of routine group; serum inflammatoryfactors IL-1, IL-6, IL-8 and hs-CRP contents were lower than those of routine group; serumoxidative stress indexes LHP and MDA contents were lower than those of routine groupwhereas CAT and GSH-Px contents were higher than those of routine group. Conclusion:Hyperbaric oxygen combined with psychotropic drug therapy can effectively increase theexpression of monoamine neurotransmitters and balance the homeostasis in patients with poststrokedepression.