Influence of hyperbaric oxygen combined with psychotropic drugs on serum neurotransmitter and cytokine contents in patients with post-stroke depression

摘要

Objective: To investigate the influence of hyperbaric oxygen combined with psychotropic drugs on serum neurotransmitter and cytokine contents in patients with post-stroke depression. Methods: A total of 62 patients with post-stroke depression who were treated in the hospital between January 2015 and February 2017 were divided into routine group (n=31) and hyperbaric oxygen group (n=31) by random number table method. Routine group received antidepressant therapy, hyperbaric oxygen group received hyperbaric oxygen combined with antidepressant therapy, and the therapies lasted for 8 weeks. The differences in the serum contents of monoamine neurotransmitters, inflammatory factors and oxidative stress indexes were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of monoamine neurotransmitters, inflammatory factors and oxidative stress indexes between the two groups before treatment. After 8 weeks of treatment, serum monoamine neurotransmitters NE, 5-HT and DA contents of hyperbaric oxygen group were higher than those of routine group; serum inflammatory factors IL-1, IL-6, IL-8 and hs-CRP contents were lower than those of routine group; serum oxidative stress indexes LHP and MDA contents were lower than those of routine group whereas CAT and GSH-Px contents were higher than those of routine group. Conclusion:Hyperbaric oxygen combined with psychotropic drug therapy can effectively increase the expression of monoamine neurotransmitters and balance the homeostasis in patients with post-stroke depression.