Effect of low protein diet combined with drug therapy on renal function and oxidation - anti-oxidation balance in patients with diabetic nephropathy

摘要

Objective: To study the effect of low protein diet combined with drug therapy on renal function and oxidation - anti-oxidation balance in patients with diabetic nephropathy. Methods: Patients with diabetic nephropathy who were treated in the Second People's Hospital of Deyang City between July 2014 and March 2017 were collected, retrospectively analyzed and then divided into two groups according to the application of low protein diet intervention or not, observation group received low protein diet combined with drug therapy, and control group accepted routine drug therapy. The contents of renal function indexes, oxidative products and antioxidant indexes in serum as well as the expression of podocyte injury markers in urine were measured before treatment and 3 months after treatment. Results: 3 months after treatment, BUN, Scr, CysC, Hcy, MDA and AOPP contents in serum as well as α-actinin-4, ZO-1, nephrin and podocinde mRNA expression in urine of both groups were lower than those before treatment whereas CAT, SOD and T-AOC contents in serum were higher than those before treatment, and BUN, Scr, CysC, Hcy, MDA and AOPP contents in serum as well as α-actinin-4, ZO-1, nephrin and podocinde mRNA expression in urine of observation group were lower than those of control group whereas CAT, SOD and T-AOC contents in serum were higher than those of control group. Conclusion: Low protein diet combined with drug therapy can improve the renal function and the oxidation - anti-oxidation balance in patients with diabetic nephropathy.