Correlation of interleukin-6 572C/G gene polymorphism with airway inflammation and remodeling in patients with COPD

摘要

Objective: To study the correlation of interleukin-6 (IL-6) 572C/G gene polymorphism with airway inflammation and remodeling in patients with COPD. Methods: Patients with stable COPD who were treated in Hanzhong Central Hospital between March 2015 and December 2017 were selected and enrolled in the COPD group of the study, and healthy volunteers who received physical examination in Hanzhong Central Hospital during the same period and had general information matched with that of patients with COPD were selected as the control group. The peripheral blood was collected to detect the IL-6 gene 572 C/G locus polymorphism, and the serum was collected to detect the levels of inflammatory response mediators and airway remodeling indexes. Results: The proportion of GG genotype in COPD group was higher than that in control group, and the proportion of GC+CC genotype was lower than that in control group; serum IL-6, IL-21, IFN-γ, CXCL13, CTRP4, CTRP5, TGF-β1, VEGF, MMP2 and NE levels of COPD group were significantly higher than those of control group whereas α1-AT and TIMP1 levels were significantly lower than those of control group, and serum IL-6, IL-21, IFN-γ, CXCL13, CTRP4, CTRP5, TGF-β1, VEGF, MMP2 and NE levels of COPD patients with GG genotype were higher than those of COPD patients with GC+CC genotype whereas α1-AT and TIMP1 levels were lower than those of COPD patients with GC+CC genotype. Conclusion: The mutation from IL-6 gene 572C/G locus allele C to G can aggravate the inflammatory response and airway remodeling in the course of COPD.