Effect of intravenous inhalational anesthesia under Narcotrend monitor on the systemic traumatic reaction after laparoscopic cholecystectomy

摘要

Objective: To study the effect of intravenous inhalational anesthesia under Narcotrendmonitor on the systemic traumatic reaction after laparoscopic cholecystectomy. Methods:A total of 116 patients with gallstone who received laparoscopic surgery in our hospitalbetween July 2012 and April 2016 were collected and divided into the combined anesthesiagroup (n=65) who accepted intravenous inhalational anesthesia under Narcotrend monitorand the intravenous anesthesia group (n=51) who accepted total intravenous anesthesia afterthe anesthesia methods and relevant test results were reviewed. 1 d after operation, enzymelinkedimmunosorbent assay (ELISA) was used to detect the serum levels of pain mediatorsand inflammation mediators; automatic biochemical analyzer was used to detect the levels ofoxidative stress indexes. Results: 1 d after operation, serum pain mediators 5-HT, PGE2, NOand HT levels of observation group were lower than those of control group; serum oxidationindexes AOPPs and LHP levels of observation group were lower than those of control groupwhile anti-oxidation indexes CAT and GSH-Px levels were higher than those of control group;serum pro-inflammatory factors IL-6, IL-8 and CRP levels of observation group were lowerthan those of control group while anti-inflammatory factors IL-4, IL-10 and IL-13 levels werehigher than those of control group. Conclusion: Intravenous inhalational anesthesia underNarcotrend monitor can reduce the postoperative systemic traumatic reaction degree in patientswith laparoscopic cholecystectomy.