Correlation of serum ASPH and 5’-NT contents with angiogenesis and cancer cell proliferation in patients with liver cancer

摘要

Objective: To proliferation in patients with liver cancer. Methods: Patients with primary livercancer who underwent surgical resection in Yulin Third Hospital between December 2013 andDecember 2016 were selected as the liver cancer group of the research, and healthy volunteerswho received physical examination in Yulin Third Hospital over the same period were selectedas the control group of the research. Serum was collected from both groups to test the contentsof ASPH and 5’-NT as well as liver cancer cell proliferation molecules; liver cancer lesionsand para-carcinoma lesions were collected from liver cancer group to detect the contents ofangiogenesis molecules and cancer cell proliferation molecules. Results: Serum ASPH and 5’-NT contents in liver cancer group were significantly higher than those in control group; VEGF,VEGFR1, VEGFR2, HGF, EGFR, Bcl-2, Bcl-x and Bcl-w contents in liver cancer lesions weresignificantly higher than those in para-carcinoma lesions and positively correlated with serumASPH and 5’-NT contents in patients with liver cancer while Bax and Bak contents in livercancer lesions were significantly lower than those in para-carcinoma lesions and negativelycorrelated with serum ASPH and 5’-NT contents in patients with liver cancer; serum AFP,GP73, GPC3 and DKK1 contents in liver cancer group were significantly higher than those incontrol group and positively correlated with serum ASPH and 5’-NT contents in patients withliver cancer. Conclusion: Serum ASPH and 5’-NT contents increase significantly in patientswith liver cancer and can accurately evaluate angiogenesis and cancer cell proliferation.