Correlation of transvaginal color Doppler ultrasound blood flow parameters of ovarian cancer with angiogenesis and cancer cell proliferation activity

摘要

Objective: To study the correlation of transvaginal color Doppler ultrasound blood flowparameters of ovarian cancer with angiogenesis and cancer cell proliferation activity. Methods:A total of 41 cases of stage I-II ovarian cancer, 27 cases of stage III-IV ovarian cancer and 35cases of benign ovarian lesions surgically removed in Obstetrics and Gynecology Departmentof Changshu No. 1 People’s Hospital Affiliated to Suzhou University between June 2014and October 2016 were collected as clinical research samples, transvaginal color Dopplerultrasound was conducted to detect blood flow parameters, and enzyme-linked immunosorbentassay experiment was used to determine the protein expression of angiogenesis genes, cellproliferation genes and tumor suppressor genes. Results: RI and PI of stage I-II ovarian cancerand stage III-IV ovarian cancer were significantly lower than those of benign ovarian lesions,and the RI and PI of stage III-IV ovarian cancer were significantly lower than those of stageI-II ovarian cancer; VEGF165, NRP-1, SphK1, SphK2, YAP, CTGF, Gli2, TNFAIP8 andLSD1 protein expression in stage I-II ovarian cancer and stage III-IV ovarian cancer lesionswere significantly higher than those in benign ovarian lesions while PTEN, MFN2 and ST7Lprotein expression were significantly lower than those in benign ovarian lesions; VEGF165,NRP-1, SphK1, SphK2, YAP, CTGF, Gli2, TNFAIP8 and LSD1 protein expression in III-IVovarian cancer lesions were significantly higher than those in stage I-II ovarian cancer lesionsand negatively correlated with RI and PI while PTEN, MFN2 and ST7L protein expressionwere significantly lower than those in I-II and ovarian cancer lesions and positively correlatedwith RI and PI. Conclusion: The decrease of transvaginal color Doppler ultrasound blood flowparameters RI and PI of ovarian cancer is closely related to the increase of angiogenesis andthe enhancement of cancer cell proliferation activity.