Effect of radiofrequency-assisted hepatectomy treatment of primary liver cancer on cancer cell apoptosis and normal liver tissue damage

摘要

Objective: To study the effect of radiofrequency-assisted hepatectomy treatment of primaryliver cancer on cancer cell apoptosis and normal liver tissue damage. Methods: 50 patientswith primary liver cancer who received surgery in our hospital between May 2011 and August2015 were collected, their operation methods and test results were reviewed, and then theywere divided into the control group (n=30) who received hepatectomy treatment alone andthe observation group (n=20) who received radiofrequency-assisted hepatectomy treatment.Intraoperative tumor tissue was collected to detect the proliferation and apoptosis gene mRNAexpression by fluorescent quantitative PCR; 3 d after operation, serum was collected to detectserum liver enzyme index levels by immune scatter turbidimetry. Results: IFITM3, NCX1,CXCR2, Cep55 and Bcl-2 mRNA expression in liver cancer tissue of observation group werelower than those of control group while Caspase-3 and Cyt-C mRNA expression were higherthan those of control group (P0.05). Conclusion: Radiofrequency-assisted hepatectomy can effectivelyinduce liver cancer cell apoptosis without increasing the normal liver tissue damage.