Progress in the pathogenesis and treatment of rheumatoid arthritis with sleep apnea hypopnea syndrome

摘要

Objective: Sleep apnea hypopnea syndrome (SAHS) is a common sleep disorder, which ismanifested as a reduction in tidal volume or apnea during sleep, which results in intermittenthypoxia and tissue hypoxia and induces oxidative stress and inflammatory responses.Rheumatoid arthritis (RA) is a systemic disease contributing to hyperplasia of synovialmembrane, cartilage erosion and joint damage. Fibroblast like synoviocytes (FLS), whichmake up the lining of the synovial membrane, are believed to play a role in the pathogenesis ofRA. RA is a series of inflammation-like responses that induce joint damage and dysfunctionand impair patients’ life quality. This article first introduced the basic features of RA andanalyzes the pathogenesis of RA with SAHS. Then the relationship between RA and SAHSwas investigated. Finally, the progress in the treatment for RA with SAHS was reviewedemphatically.