Correlation of serum thyroglobulin and anti-thyroglobulin antibody levels with pulmonary metastasis and bone metastasis in patients with thyroid cancer

摘要

Objective: To study the correlation of serum thyroglobulin (TG) and anti-thyroglobulinantibody (TGAb) levels with pulmonary metastasis and bone metastasis in patients withthyroid cancer. Methods: Patients with thyroid cancer who underwent surgical resection in ourhospital were selected as the research subjects, and the patients without distant metastasis, withpulmonary metastasis and with bone metastasis were screened and enrolled in non-metastasisgroup, pulmonary metastasis group and bone metastasis group respectively. Serum wascollected to determine the levels of TG and TGAb, and metastatic lesion tissue was collectedto determine the expression proliferation-related molecules Bcl-2, Skp-2, caspase-3 and p27as well as invasion molecules S100A4, MMP2, MMP13, SATB1 and Vimentin. Results: Thepositive rates of serum TGAb and TG of pulmonary metastasis group and bone metastasisgroup were significantly higher than those of non-metastasis group; S100A4, MMP2, MMP13,SATB1, Vimentin, Bcl-2 and Skp-2 mRNA contents in metastatic lesions of patients withpositive serum TG and TGAb were significantly higher than those of patients with negativeserum TG and TGAb while caspase-3 and p27 mRNA contents were significantly lower thanthose of patients with negative serum TG and TGAb. Conclusion: The increase of serum TGand TGAb contents is associated with the pulmonary metastasis and bone metastasis afterthyroid carcinoma surgery, and has promoting effect on the proliferation and invasion of cancercells in metastatic lesions.