Effect of hydromorphone applied in the gynecological laparoscopic operation and its effect on the hemodynamics and inflammatory cytokines

摘要

Objective: To study the effect of hydromorphone applied in the gynecological laparoscopicoperation and analyze its effect on the hemodynamics and inflammatory cytokines. Methods:A total of 170 patients who were underwent selective gynecological laparoscopic operationunder general anesthesia were included in the study and randomized into the observationgroup (n=85) and the control group (n=85). On the basis of routine anesthesia, the patientsin the observation group were given hydromorphone, while the patients in the control groupwere given fentanyl. The hemodynamic changes in different timing points in the two groupswere observed and compared. The levels of serum inflammatory cytokines and stress reactionindicators in the two groups were detected and compared. Results: HR, SBP, and MAP at T2in the observation group were significantly reduced when compared with at T1, those at T3were recovered to levels at T1. HR, SBP, and MAP at T2 and T3 in the control group weresignificantly reduced, and those were significantly lower than those in the observation group.IL-6, IL-10, and TNF-α levels 24 h after anesthesia in the two groups were significantlyelevated when compared with before anesthesia. IL-10 level in the observation group wassignificantly higher than that in the control group, while IL-6 and TNF-α were significantlylower than those in the control group. CRP, FC, A, and NE levels 24 h after anesthesia in thetwo groups were significantly reduced, and those in the observation group were significantlylower than those in the control group. Conclusions: Hydromorphone applied in thegynecological laparoscopic operation will not produce great effect on the hemodynamics, withsmall stress reaction and mild inflammatory reaction; therefore, it is more beneficial for thepostoperative recovery.