Relationship of Vitamin D deficiency with Lipid metabolism, micro-inflammatory response and endothelial injury in obese children

摘要

Objective: To study the relationship of vitamin D deficiency with lipid metabolism, microinflammatoryresponse and endothelial injury in obese children. Methods: a total of 68 casesof obese children who received examination in our hospital were chosen as obese group,56 cases of overweight children who received examination in our hospital were chosen asoverweight group, and 50 cases of normal children who received vaccination in our hospitalwere chosen as normal control group. The differences in peripheral blood 1,25-(OH)D3 contentas well as serum contents of lipid metabolism, micro-inflammatory reaction and endothelialinjury indexes were compared among three groups. Pearson test was used to evaluate theinternal relationship between 1, 25-(OH)D3 and the degree of environmental disturbance inobese children. Results: 1,25-(OH) D3 contents in obese group and overweight group werelower than that in normal control group, and 1,25-(OH) D3 content in obese group was lowerthan that in overweight group. Serum contents of lipid metabolism indexes TC, TG and LDL-Cin obese group and overweight group were higher than those in normal control group whileHDL-C content was lower than that in normal control group; contents of micro-inflammationindexes CRP, IL-6 and TNF-α were higher than those in normal control group; serumcontent of endothelial injury index ET-1 was higher than that in normal control group whileNO, CGRP and PGI2 contents were lower than those in normal control group; the changes inserum contents of above indexes in obese group were larger than those in overweight group.Conclusion: There is vitamin D deficiency in obese children, and the degree of deficiencyis directly related to the degree of abnormal lipid metabolism, micro-inflammation andendothelial injury.